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Ganciclovir sodium

Product NameGanciclovir sodium
CAS107910-75-8
MFC9H14N5NaO4
MW279.23
EINECS641-368-8
MOL File107910-75-8.mol

Chemical Properties

storage temp.	Store at 4°C, protect from light
solubility	DMSO: 5 mg/mL (17.91 mM)
form	Solid
color	White to off-white
Water Solubility	Water: 50 mg/mL (179.06 mM)
InChI	InChI=1S/C9H13N5O4.Na.H/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);;
InChIKey	HKZYYRUGZQKKFS-UHFFFAOYSA-N
SMILES	C(N1C=NC2C(NC(N)=NC1=2)=O)OC(CO)CO.[NaH]

Usage And Synthesis

Uses

Ganciclovir Sodium Salt is an inhibitor of the Herpesvirus family. It can be used in analytical study of establishment of a Raman database for non-invasive and rapid screening of liquid injectables.

brand name

Cytovene (Roche).

in vivo

Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear^[3].
Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality^[6].

Animal Model:	Non-inbred Oncins France 1 (OF1) mice and albino rats non-immunized for MCMV^[3]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, twice a day for five injections (mice) or 3 days (adult rats) (Pharmacokinetic Study)
Result:	In adult rats, the intracochlear diffusion of Ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of Ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection. Significantly decreased white blood cells, red blood cells and platelets in newborn mice.

Animal Model:	Female SCID mice inoculated with MCMV^[6]
Dosage:	0, 1, 10, 80 and 160 mg/kg
Administration:	Subcutaneous injection, once daily for 5 days
Result:	Dose dependently delayed the wasting syndrome and mortality in a dose range up to 80 mg/kg per day, whereas a dose of 160 mg/kg per day induced reversible side-effects.

IC 50

CMV; HSV-1; HSV-2; FHV-1: 5.2 μM (IC₅₀)

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