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Glycocholic acid

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Glycocholic acid Basic information
Glycocholic acid Chemical Properties
  • Melting point:128°C
  • Boiling point:568.76°C (rough estimate)
  • Density 1.1336 (rough estimate)
  • refractive index 1.6000 (estimate)
  • storage temp. Refrigerator
  • solubility methanol: 0.1 g/mL, clear, colorless
  • pka4.4(at 25℃)
  • Water Solubility 329.9mg/L(20 ºC)
  • Merck 13,4507
  • CAS DataBase Reference475-31-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceGlycocholic acid(475-31-0)
Safety Information
  • Hazard Codes N
  • Risk Statements 51/53
  • Safety Statements 61
  • RIDADR UN 3077 9/PG 3
  • WGK Germany 3
MSDS
Glycocholic acid Usage And Synthesis
  • DescriptionN-Cholylglycine. Bile salt, conjugate of cholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.
  • Chemical PropertiesOff-White Solid
  • UsesLabelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt.
  • DefinitionChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component.
  • Purification MethodsGlycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.]
Glycocholic acid Preparation Products And Raw materials
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