C2 ceramide

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.

White Crystalline Solid

Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases

A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2

ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.

A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .

Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.

Desiccate at -20°C

[1] ALFREDO MIÑANO. C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3[J]. Journal of Neuroscience Research, 2008, 86 8: 1734-1747. DOI:10.1002/jnr.21633
[2] ALESSANDRO PRINETTI. Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells[J]. FEBS Letters, 1997, 414 2: Pages 475-479. DOI:10.1016/s0014-5793(97)00981-2
[3] Y ZHANG. Kinase suppressor of Ras is ceramide-activated protein kinase.[J]. Cell, 1997, 89 1: 63-72. DOI:10.1016/s0092-8674(00)80183-x
[4] Y. MATSUZAKA. Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice[J]. PLoS ONE, 2016, 11 1. DOI:10.1371/journal.pone.0167811
[5] Y. MATSUZAKA. Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice[J]. PLoS ONE, 2016, 11 1. DOI:10.1371/journal.pone.0167811