N-ARACHIDOYL-D-ERYTHRO-SPHINGOSINE

Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types. C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized de novo by ceramide synthases 1 and 2.

white powder

C20 Ceramide (cas# 7344-02-7) is a compound useful in organic synthesis.

ChEBI: N-icosanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as eicosanoyl. It has a role as a mouse metabolite. It is a N-acylsphingosine and a Cer(d38:1). It is functionally related to an icosanoic acid.

Human Endogenous Metabolite

[1] COWART L A. Sphingolipids: players in the pathology of metabolic disease.[J]. Trends in Endocrinology and Metabolism, 2009, 20 1: 34-42. DOI: 10.1016/j.tem.2008.09.004
[2] YAEL PEWZNER-JUNG  Anthony H F  Shifra Ben Dor. When do Lasses (longevity assurance genes) become CerS (ceramide synthases): Insights into the regulation of ceramide synthesis.[J]. The Journal of Biological Chemistry, 2006, 281 35: 25001-25005. DOI: 10.1074/jbc.r600010200