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Nitrazepam

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Nitrazepam Basic information
Nitrazepam Chemical Properties
  • Melting point:223-227?C
  • Boiling point:423.94°C (rough estimate)
  • Density 1.2309 (rough estimate)
  • refractive index 1.5700 (estimate)
  • Flash point:2℃
  • storage temp. Controlled Substance, -20°C Freezer
  • solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent).
  • pkapKa 2.90 ± 0.05;10.39±0.04(H2O,t =25,I=0.015(KCl))(Approximate)
  • form neat
  • Water Solubility 3.93mg/L(25 ºC)
  • CAS DataBase Reference146-22-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceNitrazepam(146-22-5)
  • EPA Substance Registry System2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- (146-22-5)
Safety Information
  • Hazard Codes Xn,F
  • Risk Statements 22-36-20/21/22-11
  • Safety Statements 36/37/39-36/37-16
  • RIDADR 3249
  • WGK Germany 3
  • RTECS DF2450000
  • HazardClass 6.1(b)
  • PackingGroup III
  • ToxicityLD50 orally in rats: 825 ±80 mg/kg (Randall)
MSDS
Nitrazepam Usage And Synthesis
  • Chemical PropertiesPink Solid
  • UsesAnticonvulsant; hypnotic. Controlled substance (depressant)
  • DefinitionChEBI: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the trea ment of epileptic spasms in infants (West's syndrome).
  • brand nameMogadon (HoffmannLaRoche).
  • Safety ProfilePoison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NOx. See also DIAZEPAM.
Nitrazepam Preparation Products And Raw materials
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