赫斯特荧光染料 33258
![赫斯特荧光染料 33258 结构式](https://img.chemicalbook.com/CAS/GIF/23491-45-4.gif)
赫斯特荧光染料 33258 性质
熔点 | 314 °C |
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密度 | 1.5099 (rough estimate) |
折射率 | 1.6300 (estimate) |
储存条件 | -20°C |
溶解度 | 在水中的溶解度10 mg/mL |
形态 | 粉末 |
颜色 | 黄色至深黄色 |
水溶解性 | SOLUBLE |
BRN | 4088183 |
稳定性 | 吸湿性 |
CAS 数据库 | 23491-45-4(CAS DataBase Reference) |
EPA化学物质信息 | Phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-, trihydrochloride (23491-45-4) |
赫斯特荧光染料 33258 用途与合成方法
IC50: 51.31±4.56 μM (HeLa cell), 32.43±3.27 μM (HL60 cell), 15.42±2.16 μM (U937 cell)
Hoechst 33258, a fluorescent compound with a head-to-tail bis-benzimidazole structure, is initially found to be cytotoxic against L1210 murine leukemia. Hoechst 33258 is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), Human promyelocytic leukemia cell (HL60) and U937 cell Line. The IC 50 determined in the case of HeLa, HL60 and U937 is 51.31±4.56, 32.43±3.27 and 15.42±2.16 μM for Hoechst 33258, respectively. The cytotoxic property of Hoechst 33258 is investigated on a panel of seven tumour cell lines of different histological origin and Madine-Darby canine kidney (MDCK) normal cells. All cell lines, except MCF-7, exposed to Hoechst 33258 exhibit GI 50 from 84×10 -6 to 191.5×10 -6 mol/dm 3 . Under the same experimental conditions, Hoechst 33258, used as a binder reference compound, stops the cell cycle in S phase and G0/G1.
安全信息
危险品标志 | Xn |
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危险类别码 | 22-36/38-36/37/38-20/21/22 |
安全说明 | 26-36-24/25-23 |
WGK Germany | 3 |
RTECS号 | SM1140500 |
F | 3-8-10 |
海关编码 | 32129000 |
毒性 | dog,LD,intravenous,> 22400ug/kg (22.4mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEASENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYEGASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS,National Technical Information Service. Vol. PB84-171206, |
赫斯特荧光染料 33258 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | B6236 | 双苯甲亚胺 H 33258 (1mg/mL水溶液) (0.2mL×5) [用于细胞染色] | 23491-45-4 | 1SET | 290 |
2024-04-30 | XW2349145401 | 赫斯特荧光染料33258 | 23491-45-4 | 25MG | 405 |