pyroxasulfone

Pyroxasulfone is an inhibitor of the biosynthesis of very-long-chain fatty acids. Pyroxasulfone is also used to control grass weed species in pre-emergence in major field crops.

Pyroxasulfone is commercially synthesised through a multi-step process that builds its unique isoxazoline-sulfonyl-pyrazole structure. The synthesis typically begins with the preparation of a substituted pyrazole intermediate, such as 5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-ylmethanol, which is then reacted with a sulfonylating agent and coupled to a dimethylisoxazoline moiety. This process involves selective fluorination, methylation, and sulfonylation steps under controlled conditions to ensure high purity and herbicidal efficacy.

Inhibition of very long chain fatty acids (VLCFA, inhibition of cell division)

Herbicide