基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 价格(试剂级) 上下游产品信息 供应商 供应信息 相关产品
网站主页  化工产品目录 分析化学  标准品  标准物质  8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃

英文名称:N-DESMETHYLCLOZAPINE
CAS号:6104-71-8
分子式:C17H17ClN4
分子量:312.8
EINECS号:636-421-7
Mol文件:6104-71-8.mol
8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 结构式

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 性质

熔点 120-125°C
沸点 502.6±60.0 °C(Predicted)
密度 1.38±0.1 g/cm3(Predicted)
闪点 9℃
储存条件 Store at RT
溶解度 可溶于氯仿(少许)、DMSO、甲醇(少许)
酸度系数(pKa) 8.49±0.10(Predicted)
形态 黄色固体
颜色 浅黄色至厚黄色
CAS 数据库 6104-71-8(CAS DataBase Reference)

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 用途与合成方法

N-Desmethylclozapine 是非典型抗精神病药 Clozapine 的主要活性代谢产物。N-Desmethylclozapine 是一种有效的、变构的部分 M1 受体激动剂 (EC50=115 nM),能通过 M1 受体激活增强海马 N-methyl-d-aspartate (NMDA) 受体电流。N-Desmethylclozapine 也是 δ-opioid 激动剂。

EC50: 115 nM (M1 receptors)
δ-opioid

The brain penetrant metabolite N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC 50 of 55 nM and was a more potent partial agonist (EC 50 , 115 nM and 50% of acetylcholine response) at this receptor than clozapine.
N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR, and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaves as an agonist at the δ-opioid receptor in the cerebral cortex and striatum.
N-desmethylclozapine (3 μM) greatly decreases the outward current in excitatory neurons, but not in inhibitory neurons. In excitatory neurons, N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine. The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1 μM pirenzepine and 1 μM atropine. N-desmethylclozapine, but not clozapine, suppressed K + channels via M1 receptors in excitatory cells.
N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation. Clozapine, N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production.
The IC 50 s of N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1 μM, 0.38 μM, and 0.67 μM, respectively. The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment, suggesting that the inhibitors act at a stage prior to viral protein translation. N-Desmethylclozapine-treated cells show a >75% reduction in negative-strand RNA levels.

N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release, respectively. In particular, N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex. However, N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex.

安全信息

危险品标志Xn,T,F
危险类别码20/22-36/37/38-39/23/24/25-23/24/25-11
安全说明22-36-45-36/37-16-7
危险品运输编号3249
WGK Germany3
危险等级6.1(b)
包装类别III

MSDS信息

语言:English
提供商:SigmaAldrich

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-08-19 HY-G0021 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 6104-71-8 5mg 800
2024-08-19 HY-G0021S1 1 mg 3200

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 上下游产品信息

8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃供应商 更多

天津凯利奇生物科技有限公司
现货
联系电话: 15076683720
产品介绍:
中文名称:8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃
英文名称:N-Desmethylclozapine
CAS:6104-71-8
纯度:>98%
包装信息:2g
备注:2g
库存量:2g
现货日期:2024/11/5 13:11:13
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
中文名称:N-去甲氯氮平/8-氯-11-(1-哌嗪基)-5H-二苯并[b,e] [1,4]吡喃
英文名称:N-DesMethyl Clozapine
CAS:6104-71-8
包装信息:100Mg,10Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
中文名称:8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃
英文名称:N-DesMethylclozapine;8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
CAS:6104-71-8
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海阿拉丁生化科技股份有限公司
联系电话:400-400-6206333 18521732826
产品介绍:
中文名称:N-去甲基氯氮平
英文名称:N-desmethylclozapine
CAS:6104-71-8
纯度:>=98%
包装信息:100mg/RMB 2399.90;25mg/RMB 799.90;5mg/RMB 195.90
备注:试剂级
深圳振强生物技术有限公司
联系电话:0755-0755-66853366 13670046396
产品介绍:
中文名称:氯氮平EP杂质C
英文名称:Clozapine EP Impurity C
CAS:6104-71-8
纯度:95% HPLC
包装信息:10mg;25mg;50mg;100mg
备注:品牌:QCS;货号:RM-C261603;可提供COA、氢谱、质谱、液相

最新发布供应信息

氯氮平EP杂质C
深圳菲斯生物科技有限公司 2024-11-07
aladdin 阿拉丁 N135216 N-去甲基氯氮平 6104-71-8 ≥98%
上海阿拉丁生化科技股份有限公司 2024-10-31

"8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃"相关产品信息