CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4].
| Animal Model: | normal rats [2] |
| Dosage: | 30 mg/kg |
| Administration: | oral administration (p.o.) |
| Result: | Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats. |
| Animal Model: | basal blood pressure in normotensive rats[4] |
| Dosage: | 40 mg/kg/day |
| Administration: | oral administration (p.o.) |
| Result: | Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia.
Lowered the increase in pulmonary resistance in isolated perfused lungs significantly.
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