依来多辛
依来多辛 性质
| 熔点 | 230 °C (decomp) |
|---|---|
| 沸点 | 1618.1±65.0 °C(Predicted) |
| 密度 | 1.289±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMF：15 mg/ml； DMSO：20 mg/ml； DMSO:PBS (pH 7.2) (1:20)：0.04 mg/ml |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.19±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| 旋光度 (Optical Rotation) | -4422 (95% Acetic Acid) |
| 序列 | {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 |
| InChIKey | AYLPVIWBPZMVSH-UHFFFAOYSA-N |
| SMILES | C(C1NC(=O)CC1)(N1CCCC1C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(=O)NC(C)C(=O)NC(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C(=O)N)CCSC)CC1C=CC=CC=1)=O |
依来多辛 用途与合成方法
依来多辛是 NK2 和 NK3 受体的特异性激动剂。
NK2 and NK3 receptors.
Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively.
Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice.
依来多辛 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-P0006 | 依来多辛 | 69-25-0 | 5mg | 900 |
| 2026-06-05 | HY-P0006 | 依来多辛 | 69-25-0 | 10mg | 1440 |
