醋酸卡贝缩宫素
醋酸卡贝缩宫素 性质
| 熔点 | 140 - 160°C |
|---|---|
| 沸点 | 1477.9±65.0 °C(Predicted) |
| 比旋光度 | D -69.0° (c = 0.25 in 1M acetic acid) |
| 密度 | 1.218±0.06 g/cm3(Predicted) |
| 储存条件 | -15°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 29.65 mg/ml in water |
| 稳定性 | 吸湿性 |
| InChIKey | NSTRIRCPWQHTIA-FOILTOEQNA-N |
醋酸卡贝缩宫素 用途与合成方法
Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (K
i
=13 nM), E123 (K
i
=56 nM), and E1234 (K
i
=37 nM).
Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile.
Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat.
| Animal Model: | Male Sprague-Dawley rats weighing between 300 and 500 g |
| Dosage: | 2, 6.4, 20 mg/kg |
| Administration: | IP; single dose |
| Result: | Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg. |
醋酸卡贝缩宫素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-17573A | 1 mg | 200 | ||
| 2024-11-08 | HY-17573A | 醋酸卡贝缩宫素 | 37025-55-1 | 5mg | 500 |
