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Abiraterone acetate

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Abiraterone acetate Basic information
Abiraterone acetate Chemical Properties
  • Melting point:127-130°C
  • Boiling point:506.7±50.0 °C(Predicted)
  • Density 1.14±0.1 g/cm3(Predicted)
  • storage temp. -20°C Freezer
  • pka5.31±0.12(Predicted)
  • form powder
  • color white to beige
Safety Information
  • WGK Germany 3
  • RTECS BV7992100
  • HS Code 2937290000
Abiraterone acetate Usage And Synthesis
  • DescriptionIn April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
  • Chemical PropertiesOff-White Solid
  • OriginatorInstitute of Cancer Research, London (United Kingdom)
  • UsesA novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
  • UsesAbiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
  • UsesA steroidal inhibitor of CYP17A1 in androgen biosynthesis
  • DefinitionChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .
  • brand nameZytiga
Abiraterone acetate(154229-18-2)Related Product Information
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