DHEA-S

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].

ChEBI: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

Human Endogenous Metabolite

[1] E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. DOI:10.1073/pnas.95.8.4089
[2] C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. DOI:10.1016/s0039-128x(99)00046-x
[3] Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. DOI:10.1089/089771503322385791