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CONESSINE

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CONESSINE Basic information
CONESSINE Chemical Properties
  • Melting point:126-127°C
  • alpha D20 +25.3° (c = 0.7 in abs alc)
  • Boiling point:479.38°C (rough estimate)
  • Density 0.9492 (rough estimate)
  • refractive index 1.5640 (estimate)
  • storage temp. Store at RT
  • solubility ethanol: ≥2mg/mL
  • form powder
  • pka10.20±0.70(Predicted)
  • color white to tan
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26
  • WGK Germany 3
  • RTECS GK7621000
CONESSINE Usage And Synthesis
  • UsesConessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
  • Usesantiamebic, antibacterial, antineoplastic, anesthetic (local)
  • DefinitionChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
  • Biological ActivityPotent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
  • Purification MethodsIt crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
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