CONESSINE

CONESSINE Structure
CONESSINE
  • CAS No.546-06-5
  • Chemical Name:CONESSINE
  • CBNumber:CB8139148
  • Molecular Formula:C24H40N2
  • Formula Weight:356.59
  • MOL File:546-06-5.mol
CONESSINE Property
  • Melting point: :126-127°C
  • alpha  :D20 +25.3° (c = 0.7 in abs alc)
  • Boiling point: :479.38°C (rough estimate)
  • Density  :0.9492 (rough estimate)
  • refractive index  :1.5640 (estimate)
  • storage temp.  :Store at RT
  • solubility  :ethanol: ≥2mg/mL
  • form  :powder
  • pka :10.20±0.70(Predicted)
  • color  :white to tan
  • FDA UNII :EZ38J9BBDF
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26
  • WGK Germany  :3
  • RTECS  :GK7621000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
CONESSINE Price More Price(15)
  • Brand: Sigma-Aldrich
  • Product number: SML0095
  • Product name : Conessine
  • Purity: ≥97% (HPLC)
  • Packaging: 10mg
  • Price: $44.7
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: SML0095
  • Product name : Conessine
  • Purity: ≥97% (HPLC)
  • Packaging: 50mg
  • Price: $161
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 11700
  • Product name : Conessine
  • Purity: ≥98%
  • Packaging: 50mg
  • Price: $98
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 11700
  • Product name : Conessine
  • Purity: ≥98%
  • Packaging: 100mg
  • Price: $186
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Usbiological
  • Product number: 255027
  • Product name : Conessine
  • Purity: 
  • Packaging: 50mg
  • Price: $395
  • Updated: 2021/12/16
  • Buy: Buy

CONESSINE Chemical Properties,Usage,Production

  • Description Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4. Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.
  • Uses Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
  • Uses antiamebic, antibacterial, antineoplastic, anesthetic (local)
  • Definition ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
  • Biological Activity Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
  • Purification Methods It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
CONESSINE Preparation Products And Raw materials
Raw materials
Preparation Products
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546-06-5, CONESSINERelated Search:
  • 3-beta-(dimethylamino)-con-5-enin
  • 3-beta-(dimethylamino)con-5-enine
  • n,18-dihydrotrimethyl-conkurchin
  • n-dimethyl-(3-beta)-con-5-enin-3-amin
  • WRIGHTINE
  • NERVINE
  • NERIINE
  • ROGUESSINE
  • ROQUESSINE
  • CONESSIN
  • CONESSINE
  • (3-BETA)-N,N-DIMETHYL-CON-5-ENIN-3-AMINE
  • 5-CONENIN-3BETA-DIMETHYLAMINE
  • CONESSINE(RG)
  • N,N-Dimethyl-con-5-enin-3-amine
  • CONESSINE(P)
  • (3β)-N,N-dimethyl-con-5-enin-3-amine
  • NSC 119994
  • Conessine (Wrightine Roguessine)
  • Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
  • 546-06-5
  • 546-06-7
  • C24H40N2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids