Basic information Description Physical and Chemical Properties Application Preparation Precautions References Safety Related Supplier
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Basic information Description Physical and Chemical Properties Application Preparation Precautions References Safety Related Supplier
Moxonidine Basic information
Moxonidine Chemical Properties
  • Melting point:217-219° (dec)
  • Boiling point:364.7±52.0 °C(Predicted)
  • Density 1.52±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at +4°C
  • solubility Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
  • pka7.11±0.10(Predicted)
  • form neat
  • Water Solubility 800.3mg/L(temperature not stated)
  • Merck 14,6293
  • CAS DataBase Reference75438-57-2(CAS DataBase Reference)
Safety Information
  • RIDADR UN 2811 6.1/PG III
  • WGK Germany 3
  • RTECS UV6260290
  • HazardClass 6.1
  • PackingGroup III
Moxonidine Usage And Synthesis
  • DescriptionMoxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
    Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
    It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
    It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
  • Physical and Chemical Propertiesensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.
  • Application
    • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
    • The intervention of renal interstitial fibrosis can protect the kidney.
  • Preparation5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.
  • Precautions
    • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
    • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.
  • References
  • DescriptionMoxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.
  • Chemical PropertiesWhite Solid
  • OriginatorBeiersdorf (Germany)
  • UsesMoxonidine is an antihypertensive agent.
  • UsesAntihypertensive;Imidazoline receptor agonist
  • brand nameCynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.
  • Biological ActivityMixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.
Moxonidine Preparation Products And Raw materials
Moxonidine(75438-57-2)Related Product Information
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Products Intro:Product Name:Moxonidine
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
  • Products Intro:Product Name:Moxonidine hydrochloride;4-Chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)-6-Methoxy-2-Methyl-5-pyriMidinaMinehydrochloride
    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
  • Company Name:TCI (Shanghai) Development Co., Ltd.
  • Tel:021-67121386 / 800-988-0390
  • Products Intro:Product Name:Moxonidine
    Purity:98.0% T Package:1G,200MG
  • Company Name:Jia Xing Isenchem Co.,Ltd
  • Tel:18627885956 0573-85285100-
  • Products Intro:CAS:75438-57-2
    Purity:98% (HPLC or GC) Package:25g,100g,500g;1kg
  • Company Name:Pure Chemistry Scientific Inc.
  • Tel:001-857-928-2050 or 1-888-588-9418
  • Products Intro:Product Name:Moxonidine
    Purity:99% Package:10Mg;50Mg