Mildiomycin is a nucleoside antibiotic isolated from the culture filtrate of
Streptoverticillium rimofaciens B-98891 (17). C19H30N8O9
(514.5). Basic and hygroscopic. Solubility: In water
580 g/L; in methanol 480; ethanol 160 (mg/L). Insoluble in
ethyl acetate and ethyl ether. Susceptible to photodegradation
by sunlight.
Specifically active against the powdery mildew pathogens;
excellent curative activity on the disease of various plants
in vivo.Used in practice for the control of powderymildews
on rose, spindle tree, and Indian lilac.
Mildiomycin remarkably inhibits protein synthesis in
E. coli. The synthesis of polypeptides in mammalian cellfree
system from rabbit reticulocytes is less sensitive to
mildiomycin than that from E. coli (18). The toxicity of
mildiomycin is low; LD50 for acute toxicity in rats and
mice is 500–1000 mg/kg by intravenous and subcutaneous
injections, and 2.5–5.0 g/kg by oral administration. At a
concentration of 1000 ppm, there is no irritation to the
cornea and skin of rabbits for 10 days.
