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2-Acetylbutyrolactone Basic information
2-Acetylbutyrolactone Chemical Properties
  • Melting point:<25 °C
  • Boiling point:107-108 °C5 mm Hg(lit.)
  • Density 1.19 g/mL at 25 °C(lit.)
  • refractive index n20/D 1.459(lit.)
  • Flash point:>230 °F
  • storage temp. -20?C Freezer, Under Inert Atmosphere
  • solubility 200g/l
  • pka12.00±0.20(Predicted)
  • form Liquid
  • color Clear
  • Water Solubility 310 g/L (20 ºC)
  • Merck 14,83
  • BRN 112676
  • Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
  • CAS DataBase Reference517-23-7(CAS DataBase Reference)
  • NIST Chemistry Reference2(3H)-Furanone, 3-acetyldihydro-(517-23-7)
  • EPA Substance Registry System2(3H)-Furanone, 3-acetyldihydro- (517-23-7)
Safety Information
  • Language:EnglishProvider:ABL
  • Language:EnglishProvider:ACROS
  • Language:EnglishProvider:SigmaAldrich
  • Language:EnglishProvider:ALFA
2-Acetylbutyrolactone Usage And Synthesis
  • DescriptionIt is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4
  • Reference
    1. Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
    2. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
    3. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
    4. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.
  • Chemical PropertiesColorless to light yellow liqui
  • UsesAn intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.
  • UsesIn synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.
2-Acetylbutyrolactone Preparation Products And Raw materials
2-Acetylbutyrolactone(517-23-7)Related Product Information
  • Company Name:Jiangsu Greature Bio-Medicine Co., Ltd. Gold
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