BAX(小鼠来源抗体)

BCL2-associated X Protein (BAX) Mouse anti-Human Monoclonal Antibody Mouse Monoclonal

Human, Monkey, Mouse, Rat

Unconjugated Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse BAX, and purified by antigen affinity chromatography. IHC - Paraffin (10 - 12 ug/ml), Western blot, Immunoprecipitation

LSBio:IHCPlus™ Monoclonal Mouse anti‑Human BCL2 / Bcl‑2 Antibody (clone 11C5, IHC, WB) LS‑B7085

Bcl-2 antibody LS-B7085 is an unconjugated mouse monoclonal antibody to human Bcl-2 (BCL2). Validated for ELISA, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.

BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP). BAX(小鼠来源抗体)以人工合成的Bax氨基端(Amino-terminal)的一段多肽为抗原制备而成的抗Bax小鼠单克隆抗体。克隆号为6A7(Clone6A7)，是应用最广的Bax抗体。抗体类型为Mouse IgG1。