描述 宿主 克隆性 种属反应性 偶联性 制备 验证的应用 品牌示例 背景 简介
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BAX(小鼠来源抗体)

描述 宿主 克隆性 种属反应性 偶联性 制备 验证的应用 品牌示例 背景 简介
BAX(小鼠来源抗体),,结构式
BAX(小鼠来源抗体)
  • CAS号:
  • 英文名:Mouse Anti-Bax （Bcl-2 Assaciated X protein）
  • 中文名:BAX(小鼠来源抗体)
  • CBNumber:CB7946413
  • 分子式:
  • 分子量:0
  • MOL File:Mol file

BAX(小鼠来源抗体)性质、用途与生产工艺

  • 描述 BCL2-associated X Protein (BAX) Mouse anti-Human Monoclonal Antibody
  • 宿主 Mouse
  • 克隆性 Monoclonal
  • 种属反应性

    Human, Monkey, Mouse, Rat

  • 偶联性 Unconjugated
  • 制备 Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse BAX, and purified by antigen affinity chromatography.
  • 验证的应用 IHC - Paraffin (10 - 12 ug/ml), Western blot, Immunoprecipitation
  • 品牌示例

    LSBio:IHCPlus™ Monoclonal Mouse anti‑Human BCL2 / Bcl‑2 Antibody (clone 11C5, IHC, WB) LS‑B7085

    Bcl‑2 Antibody (clone 11C5, IHC, WB) LS‑B7085
    Bcl-2 antibody LS-B7085 is an unconjugated mouse monoclonal antibody to human Bcl-2 (BCL2). Validated for ELISA, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.

  • 背景 BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP).
  • 简介 BAX(小鼠来源抗体)以人工合成的Bax氨基端(Amino-terminal)的一段多肽为抗原制备而成的抗Bax小鼠单克隆抗体。克隆号为6A7(Clone6A7)，是应用最广的Bax抗体。抗体类型为Mouse IgG1。
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