Ethiazide,Tokyo Tanabe,Japan,1970
A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of
anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and
0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams
hydrogen chloride per 1,000 ml) is heated to 80° to 90°C and maintained at
that temperature for 1 hour. The reaction mixture is concentrated under
reduced pressure; on addition of water, the product separates and is then
recrystallized from ethanol or aqueous ethanol to yield the desired 6-chloro-3-
ethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to
270°C.
Diuretic, Cardiotonic, Smooth muscle relaxant,
Respiratory stimulant
