2,4,6-Trichloropyridine

2587-00-0

16063-69-7

2,6-Dichloropyridine-N-oxide (Y-2) (8.20 g, 0.050 mol) was used as a raw material, which was dissolved in phosphorus trichloride (POCl3, 25 mL) and the reaction was carried out at reflux for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into crushed ice and extracted with petroleum ether (3 x 50 mL). The organic phases were combined, dried with anhydrous potassium carbonate (K2CO3), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using a mixed solvent of ethyl acetate/petroleum ether as eluent, resulting in colorless needle-like crystals of 2,4,6-trichloropyridine (Y-3) in 85% yield with a melting point of 32-33 °C. The final product was extracted from the crude product using a mixture of ethyl acetate/petroleum ether as eluent, and then dried with anhydrous potassium carbonate (3 × 50 mL).