3-Ethynylthiophene

3-Ethynylthiophene is used in preparation of benzothiazonines by rhodium-catalyzed denitrogenative annulation reactions of sulfonylaryltriazoles with thiochromones.

3-Ethynylthiophene may be used in the synthesis of the following:

• 1-(2-bromobenzyl)-4-(thiophen-3-yl)-1H-1,2,3-triazole which is obtained by heating with 2-iodophenylethylazide in the presence of copper acetate monohydrate catalyst in N-methyl-2-pyrrolidone
• N-benzyl-1-phenyl-5-(thiophen-3-yl)-4-pentyn-2-amine via a multi-step reaction process
• [(C₄H₃S-3)C≡CAg]_n, a polymeric compound obtained via reaction with silver nitrate in the presence of triethylamine in acetonitrile
• 4,5-bis(thiophen-3-ylethynyl)phthalonitrile via Sonogashira cross-coupling reaction with 4,5-dichlorophthalonitrile