Phenyl N-Phenylphosphoramidochloridate is a phosphorylating agent in oligonucleotide synthesis via the phosphotriester approach; for the conversion of
acids to their symmetrical anhydrides and for the coupling of acids and amines to give amides; two
important derivatives are also considered.
Phenyl N-Phenylphosphoramidochloridate is obtained from phenyl phosphorodichloridate (2) and aniline (eq 1).
[1]
Phenyl N-Phenylphosphoramidochloridate is irritating and moisture-sensitive. It may be harmful by inhalation (irritating
to mucous membranes and upper respiratory tract), ingestion, or skin absorption. Incompatible with strong
oxidizing agents and strong bases.
1. Cremlyn, R. W. J.; Kishore, D. N. JCS(P1) 1972, 585.
