香胶甾酮
香胶甾酮 性质
| 沸点 | 463.3±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.10±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度为5 毫克/毫升 |
| 形态 | 粉末 |
| 颜色 | 浅黄色 |
| InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/t15-,17+,18+,20+,21-/m1/s1 |
| InChIKey | WDXRGPWQVHZTQJ-NRJJLHBYSA-N |
| SMILES | C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=CC)C(=O)C3)CC2 |
| CAS 数据库 | 95975-55-6(CAS DataBase Reference) |
香胶甾酮 用途与合成方法
香胶甾酮是一种植物甾醇，来自 Commiphora wightii 树的树胶脂。 香胶甾酮通过下调抗细胞凋亡 (apoptosis) 基因产物 (IAP1，xIAP，Bfl-1/A1，Bcl-2，cFLIP，survivin)，调节细胞周期蛋白 (cyclin D1，c-Myc)，激活 caspases，JNK，抑制 Akt，抑制多种肿瘤细胞的生长并诱导细胞凋亡。香胶甾酮通过调节几种转录因子介导基因表达，包括 NF-κB，STAT3，C /EBPα，雄激素受体 (androgen receptor) 和糖皮质激素受体(glucocorticoid receptors)。它是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
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JNK
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Akt
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Caspase
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Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.
Western Blot Analysis
| Cell Line: | RAW 264.7 murine macrophage cells |
| Concentration: | 0.5, 5, 10, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS. |
Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis.
| Animal Model: | Wild-type mice with TNBS-induced colitis |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
| Result: | Improved the survival rates of wild-type mice with TNBS-induced colitis. |
香胶甾酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-05-22 | XW9597555602 | 试剂Guggulsterone E&Z | 95975-55-6 | 5mg | 347 |
| 2025-05-22 | XW9597555601 | 试剂Guggulsterone E&Z | 95975-55-6 | 25mg | 734 |
