雄酮
雄酮 性质
| 熔点 | 181-184 °C(lit.) |
|---|---|
| 沸点 | 372.52°C (rough estimate) |
| 比旋光度 | 96 º (c=1, C2H5OH) |
| 密度 | 1.0320 (rough estimate) |
| 折射率 | 1.4709 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | 乙腈：1mg/mL；乙醇：1mg/mL；甲醇：1mg/mL |
| 酸度系数(pKa) | 15.14±0.60(Predicted) |
| 水溶解性 | 11.5mg/L(23.5 ºC) |
| Merck | 13,645 |
| BRN | 2217626 |
| CAS 数据库 | 53-41-8(CAS DataBase Reference) |
| NIST化学物质信息 | Androsterone(53-41-8) |
| EPA化学物质信息 | Androsterone (53-41-8) |
雄酮 用途与合成方法
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Human Endogenous Metabolite
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Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).
雄酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-11 | XW00534183 | 雄酮 | 53-41-8 | 1G | 306 |
| 2024-11-11 | XW00534182 | 雄酮 | 53-41-8 | 5G | 1045 |
