尿石素C
尿石素C 性质
| 熔点 | >300°C |
|---|---|
| 沸点 | 605.4±55.0 °C(Predicted) |
| 密度 | 1.640±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、加热） |
| 酸度系数(pKa) | 7.51±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅棕色 |
| 稳定性 | 吸湿性 |
| LogP | 1.615 (est) |
尿石素C 用途与合成方法
Insulin secretion
L-type Ca
2+
channel
Reactive oxygen species (ROS)
Apoptosis
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells.
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis.
Urolithin C treatment induces apoptosis and S phase cell cycle arrest.
Western Blot Analysis
| Cell Line: | INS-1 cells |
| Concentration: | 20 μM, 100 μM |
| Incubation Time: | 1 hour |
| Result: | Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation. |
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.
尿石素C 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-135897 | 5 mg | 620 | ||
| 2024-11-08 | HY-135897 | 尿石素C | 165393-06-6 | 10mM * 1mLin DMSO | 680 |
