Urotensin II (114-124), human TFA

基本属性生物活性靶点体外研究体内研究用途与合成方法相关产品

Urotensin II (114-124), human TFA

中文名称:Urotensin II (114-124), human TFA

英文名称:Urotensin II (114-124), human TFA

CAS号:

分子式:C??H??F?N??O??S?

分子量:0

EINECS号:

Mol文件:Mol File

Urotensin II (114-124), human TFA 性质

形态	固体
颜色	白色至米白色

Urotensin II (114-124), human TFA 用途与合成方法

生物活性

Urotensin II (114-124), human TFA 是一个含 11 个氨基酸的残基肽，是孤儿受体 GPR14 激动剂，是一有效血管收缩剂。

靶点

GPR14

体外研究

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC ₅₀ =0:62±0.17 nM, n=6).

体内研究

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.

"Urotensin II (114-124), human TFA"相关产品信息

人尿皮质素 ILE-VAL-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-GLN-ILE-LEU-LEU-GLU-GLN-ALA-ARG-ALA-ARG-ALA-ALA-ARG-GLU-GLN-ALA-THR-THR-ASN-ALA-ARG-ILE-LEU-ALA-ARG-VAL-GLY-HIS-CYS-NH2 尿石素C ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL 硬骨鱼紧张肽尿石素A UROTENSIN II UROTENSIN II (HUMAN)