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WORTMANNIN

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WORTMANNIN Basic information
WORTMANNIN Chemical Properties
  • Melting point:234-240 °C
  • alpha +80.0~+105.0゜(20℃/D)(c=0.1,C2H5OH)
  • Boiling point:463.31°C (rough estimate)
  • Density 1.2454 (rough estimate)
  • refractive index 1.4480 (estimate)
  • Flash point:2℃
  • storage temp. 2-8°C
  • solubility DMSO: soluble
  • form powder
  • color off-white
  • λmax296nm(lit.)
  • Sensitive Light Sensitive
  • Merck 14,10053
  • BRN 67676
Safety Information
MSDS
WORTMANNIN Usage And Synthesis
  • Chemical PropertiesWhite to pale yellow powder
  • UsesWortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumour and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.
  • Biological ActivityPotent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM).
WORTMANNIN(19545-26-7)Related Product Information
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