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ChemicalBook Product Catalog API Antibiotics Penicillins drugs Wortmannin

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Wortmannin NEW

$32.00 1mg

$45.00 2mg

$72.00 5mg

Min. Order
Purity99.76%
Cas No19545-26-7
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Wortmannin
CAS No	19545-26-7
EC-No
Min. Order
Purity	99.76%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Wortmannin
Description	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
In vitro	METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (50-500 nM) for 24 h. Cell death was detected by Trypan blue exclusion assay. RESULTS: Wortmannin induced cell death in MCF-7 cells in a concentration-dependent manner with an IC50 of 400 nM. [1] METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (6.25-50 nM) for 24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Concentration-dependent reduction of p-Akt and NF-κB p65 expression was induced by Wortmannin. [2]
In vivo	METHODS: To determine whether activation of the insulin pathway and brain enlargement were responsible for fatal seizures, Wortmannin (1.5 mg/kg) was administered orally to Pcmt1-/- mice once a day for twenty-two days. RESULTS: Wortmannin reduced the average brain size of Pcmt1-/- mice to within 6% of that of controls and nearly doubled the lifespan of Pcmt1-/- mice, with a survival rate of 60% of the original population. [3] METHODS: To investigate antitumor activity, Wortmannin (0.25-1 mg/kg) was injected intravenously three times a week for three weeks into SCID mice bearing the human breast cancer tumor MDA-MB-231. RESULTS: Wortmannin significantly inhibited tumor metastasis and angiogenesis. [4]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 2.1 mg/mL (5 mM)), Heating is recommended. DMSO : 21.4 mg/mL (50 mM)
Keywords	KY12420 \| Antibiotic \| SL 2052 \| PI3K \| inhibit \| Wortmannin \| Autophagy \| Polo-like Kinase (PLK) \| KY 12420 \| Phosphoinositide 3-kinase \| Inhibitor \| SL2052
Inhibitors Related	Neomycin sulfate \| Stavudine \| Ampicillin sodium \| Kanamycin sulfate \| Sulfamethoxazole sodium \| Hydroxychloroquine \| Guanidine hydrochloride \| Doxycycline \| Paeonol \| Naringin
Related Compound Libraries	Anti-Pancreatic Cancer Compound Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Autophagy Compound Library \| Inhibitor Library \| Microbial Natural Product Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Preclinical Compound Library \| Anti-Cancer Active Compound Library

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