| Name | Wortmannin |
| Description | Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy. |
| In vitro | METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (50-500 nM) for 24 h. Cell death was detected by Trypan blue exclusion assay.
RESULTS: Wortmannin induced cell death in MCF-7 cells in a concentration-dependent manner with an IC50 of 400 nM. [1]
METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (6.25-50 nM) for 24 h. The expression levels of target proteins were detected by Western Blot.
RESULTS: Concentration-dependent reduction of p-Akt and NF-κB p65 expression was induced by Wortmannin. [2] |
| In vivo | METHODS: To determine whether activation of the insulin pathway and brain enlargement were responsible for fatal seizures, Wortmannin (1.5 mg/kg) was administered orally to Pcmt1-/- mice once a day for twenty-two days.
RESULTS: Wortmannin reduced the average brain size of Pcmt1-/- mice to within 6% of that of controls and nearly doubled the lifespan of Pcmt1-/- mice, with a survival rate of 60% of the original population. [3]
METHODS: To investigate antitumor activity, Wortmannin (0.25-1 mg/kg) was injected intravenously three times a week for three weeks into SCID mice bearing the human breast cancer tumor MDA-MB-231.
RESULTS: Wortmannin significantly inhibited tumor metastasis and angiogenesis. [4] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 2.1 mg/mL (4.9 mM), Heating is recommended.
DMSO : 21.4 mg/mL (49.95 mM), Sonication is recommended.
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| Keywords | Wortmannin | threoninkinase | threonin kinase | SL2052 | SL 2052 | Serinekinase | Serine kinase | Polo-like Kinase (PLK) | PLK | PI3K | Phosphoinositide 3-kinase | MLCK | KY12420 | KY 12420 | Inhibitor | inhibit | DNA-PK | DNAPK | Autophagy | ATR | ATM/ATR | ATM | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Stavudine | Aceglutamide | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | Doxycycline | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Natural Product Library | Inhibitor Library | Microbial Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
