PKG Inhibitor (trifluoroacetate salt)

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM).1 This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.1 PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.2WARNING This product is not for human or veterinary use.

[1] GLASS D B. Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors.[J]. Biochemical Journal, 1983, 213 1: 159-164. DOI: 10.1042/bj2130159
[2] E M WEXLER  S N  P K Stanton. Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase.[J]. Journal of Neuroscience, 1998, 18 7: 2342-2349.