NF-κB Inhibitor (trifluoroacetate salt)

NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1 It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1 In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3 This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5WARNING This product is not for human or veterinary use.

[1] Y Z LIN. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence.[J]. The Journal of Biological Chemistry, 1995, 270 24: 14255-14258. DOI: 10.1074/jbc.270.24.14255
[2] T. TORGERSON. Regulation of NF-κB, AP-1, NFAT, and STAT1 Nuclear Import in T Lymphocytes by Noninvasive Delivery of Peptide Carrying the Nuclear Localization Sequence of NF-κB p50[J]. The Journal of Immunology, 1998, 8 1. DOI: 10.4049/jimmunol.161.11.6084
[3] S KASIBHATLA  D R G  L Genestier. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.[J]. The Journal of Biological Chemistry, 1999, 274 2: 987-992. DOI: 10.1074/jbc.274.2.987
[4] LAURENT METHOT. Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.[J]. Molecular and Cellular Biology, 2013, 33 14: 2797-2808. DOI: 10.1128/mcb.01610-12
[5] P. WÄSTER  K. Ö  I Rosdahl. Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet B[J]. British Journal of Dermatology, 2014, 171 6: 1336-1346. DOI: 10.1111/bjd.13278
[6] WEI YANG. Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR.[J]. Journal of Pharmacology and Experimental Therapeutics, 2020, 372 3: 277-284. DOI: 10.1124/jpet.119.263160