PKA Inhibitor (5-24) (trifluoroacetate salt)

PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1 It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.1 The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).2WARNING This product is not for human or veterinary use.

[1] HEUNG-CHIN CHENG. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.[J]. The Journal of Biological Chemistry, 1986, 151 1: 989-992. DOI: 10.1016/s0021-9258(17)36041-6
[2] D BOSSEMEYER. Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).[J]. EMBO Journal, 1993, 12 3: 849-859. DOI: 10.1002/j.1460-2075.1993.tb05725.x