KYL (trifluoroacetate salt)

KYL is a 12-amino acid synthetic peptide and an inhibitor of the Eph tyrosine kinase receptor A4 (EphA4; IC50 = 4.22 µM).1 KYL inhibits EphA4-induced growth cone collapse in embryonic chicken retina explants when used at a concentration of 5 µM.2WARNING This product is not for human or veterinary use.

[1] BAINAN WU. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.[J]. Chemistry & biology, 2013, 20 1: 19-33. DOI: 10.1016/j.chembiol.2012.10.015
[2] ROBERTA NOBERINI. Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.[J]. The Journal of Biological Chemistry, 2008: 29461-29472. DOI: 10.1074/jbc.m804103200