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Naltrexone hydrochloride

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Naltrexone hydrochloride Basic information
Naltrexone hydrochloride Chemical Properties
  • Melting point:274-2760C
  • storage temp. 2-8°C
  • solubility H2O: 50 mg/mL, clear, colorless
  • form neat
  • Water Solubility Soluble in water at 50mg/ml.
  • Sensitive Light Sensitive
  • Merck 13,6389
  • BRN 3580333
  • CAS DataBase Reference16676-29-2(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 22-36
  • WGK Germany 3
  • RTECS QD2160000
  • 8-10
Naltrexone hydrochloride Usage And Synthesis
  • DescriptionNaltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.
  • Chemical PropertiesWhite Crystalline Powder
  • OriginatorEndo (USA)
  • UsesNonselective opioid receptor antagonist; congener of naloxone
  • UsesAnalgesic;Opioid antagonist
  • Usessulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent
  • UsesNarcotic antagonist, In treatment of?alcoholism
  • brand nameTREXAN
  • Biological ActivityOpioid antagonist.
  • Purification MethodsThis narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]
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