Gly-Gly-Leu

White crystalline powder

Gly-gly-leu is an oligopeptide, and also functions as a plant growth regulator.

ChEBI: Gly-Gly-Leu is a tripeptide composed of glycine, glycine and L-leucine residues joined in sequence. It has a role as a metabolite.

Glycylglycyl-L-leucine was prepared in 98% yield by hydrogenolysis of the protected tripeptide and crystallization of the product from aqueous ethanol. This matarial had [α]²⁴_D -28.4° (c, 2 in water), reported [α]²⁰_D -28. l° (c, 2.53 in water), [α]²⁶_D -28.0°, and [α]19_D -29.9° (c, 2 in water)[1].

[1] Beechham A, et al. Residue rotations of L-leucine in the Di-, Tri-, Tetra-, and Penta-peptides of L-leucine and Glycine containing one L-leucyl residue. Australian Journal of Chemistry, 1967; 20: 1983 - 1989.
[2] OREN ROM. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome[J]. Science Translational Medicine, 2020, 12 572. DOI: 10.1126/scitranslmed.aaz2841
[3] PENGXIANG QU. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates.[J]. Cell metabolism, 2023, 35 5: 742-757.e10. DOI: 10.1016/j.cmet.2023.03.013