4-oxopiperidinium chloride

Product Name4-oxopiperidinium chloride
CAS41979-39-9
MFC5H10ClNO
MW135.592
EINECS255-602-8
MOL File41979-39-9.mol

Chemical Properties

Melting point	145.5-147 °C(Solv: acetonitrile (75-05-8))
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	solid
color	Yellow
InChI	InChI=1S/C5H9NO.ClH/c7-5-1-3-6-4-2-5;/h6H,1-4H2;1H
InChIKey	GJQNVZVOTKFLIU-UHFFFAOYSA-N
SMILES	[NH2+]1CCC(=O)CC1.[Cl-]

Safety Information

HazardClass	IRRITANT
HS Code	2914390090

Usage And Synthesis

Physical Form

White to yellow solid

synthesis

To a solution of tert-butyl 4-oxopiperidine-1-carboxylate (2300 g, 11.6 mol) in 1,4-dioxane was added a solution of HCl (g)/1,4-dioxane (4 L, 10 mol/L) slowly at 0°C. After the addition, the reaction mixture was stirred for 4 h and TLC (EtOAc/petroleum ether = 1:5) showed the reaction was complete. The solvent was removed in vacuo to afford piperidin-4-one hydrochloride as a brown solid.

Fig The synthetic method of 4-oxopiperidinium chloride

Uses

4-oxopiperidinium chloride is a useful research chemical.

Preparation Products And Raw materials

Preparation Products

1-Cbz-4-Piperidone 2-Piperidone Remifentanil Hydrochloride N-phenylpiperidin-4-amine 2-(triMethylsilyl)ethyl 4-(trifluoroMethylsulfonyloxy)-5,6-dihydropyridine-1(2H)-carboxylate 1H-Pyrido[4,3-b]indole, 6-bromo-2,3,4,5-tetrahydro-, hydrochloride (1:1)methyl 4-oxopiperidine-1-carboxylate 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID tert-butyl 4,4-difluoropiperidine-1-carboxylate 1-FMOC-4-PIPERIDONE 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine SERTINDOLE ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE