Ethyl 4-piperidone-3-carboxylate hydrochloride

1454-53-1

4644-61-5

General procedure for the synthesis of ethyl piperidin-4-one-3-carboxylate hydrochloride from ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride: in a 50 mL reactor, ethyl N-benzyl-4-oxo-piperidine-3-carboxylate hydrochloride (12 g, 40.29 mmol) and Pd(OH)2/C catalyst (120 mg, 1 wt%) were added. The reaction was stirred for 48 h under 5 bar hydrogen pressure using a dry solvent mixture of dichloromethane and methanol (4:1, v/v) as the reaction medium. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad followed by evaporation of the solvent under reduced pressure to afford 8.3 g of the target product, ethyl piperidin-4-one-3-carboxylate hydrochloride, as a light brown solid in 99% yield.