4-Methoxy-1-indanone

• Synthesis of isomeric mixture of oximes.
• As a starting material in the synthesis of benzo-fused indolizidine and 4-methoxy-1-indanyl compound.
• Synthesis of 4-methoxy-5-nitro-1-indanone by nitration reaction.
• As one of the reactant in the synthesis of E-2-chloro-8-methyl-3-[(4′-methoxy-1′-indanoyl)-2′-methyliden]-quinoline (IQ), a quinoline derivative.

40731-98-4

74-88-4

13336-31-7

The reaction was carried out with 4-hydroxy-1-indanone (125 mg) and iodomethane (263 μL) in the presence of potassium carbonate (350 mg) in N,N-dimethylformamide (DMF, 4 mL) for 3 h at 50 °C with stirring. After completion of the reaction, the mixture was poured into 1N hydrochloric acid (20 mL) and extracted with ether (4 × 10 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give 4-methoxy-1-indanone intermediate as a clear oil (131 mg, 96% yield). Mass spectral analysis showed [MH]+ = 163.