1-Indanone

Pale yellow liquid

1-Indanone is an oxidation product of indan, a component of fuels, solvents and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces.

1-Indanone is an oxidation product of Indan, a component of fuels, solvents, and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces.

ChEBI: An indanone that consists of 2,3-dihydro-1H-indene substituted by an oxo group at position 1.

The Journal of Organic Chemistry, 54, p. 1144, 1989 DOI: 10.1021/jo00266a028
Journal of the American Chemical Society, 99, p. 4822, 1977 DOI: 10.1021/ja00456a048
Tetrahedron Letters, 27, p. 3139, 1986 DOI: 10.1016/S0040-4039(00)84736-X

Indoleamine 2,3 dioxygenase (IDO) 1 plays an important role in the metabolism of tryptophan and in immune regulation. Removal of IDO1 results in attenuated contact hypersensitivity (CHS) responses.

1-Indanone is produced by cyclization of be{a-Phenylpropionyl chloride in Benzene.