阿米卡星硫酸盐(5:9)
阿米卡星硫酸盐(5:9) 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | H2O中可溶50mg/mL |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| InChIKey | HIBICIOPDUTNRR-BOEHXBESSA-N |
阿米卡星硫酸盐(5:9) 用途与合成方法
Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by
Nocardia asteroides
,
Mycobacterium avium-intracellulare
, and certain species of "rapid-growing" mycobacteria (that is,
M. chelonae
and
M. fortuitumi
).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD
50
value of 453 μM.
Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
| Animal Model: | Male Fischer 344 rats (40-50-day-old) |
| Dosage: | 320 mg/kg |
| Administration: | Subcutaneous injection; daily; for 10 days |
| Result: | Induced hearing loss in rats. |
