Anilofos is an organophosphate herbicide used to control annual grass weeds and sedges. It has a low aqueous solubility and a low volatility. It may be moderately persistent in soil systems depending on conditions. It moderately toxic to fish, aquatic invertebrates and honeybees but less so to birds. Anilofos is moderately toxic to mammals via the oral route. It is also a neurotoxin and a recognised irritant.
Selective, absorbed mainly through roots and works by inhibiting cell division. Inhibition of very long chain fatty acids (VLCFA, inhibition of cell division)
Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, POx, SOx, and Cl-.
1. Synthesis of N-isopropyl-p-chloroaniline
Add p-chloroaniline, 2-bromopropane sequentially to the reaction kettle, heating and stirring, after reacting at a certain temperature for several hours, cooling, adding sodium hydroxide solution and stirring the stratification, the oil layer is washed with water to neutral, the aqueous layer is extracted with a solvent, combining the oil layers, desolventizing to get a purplish-red liquid or distillation under reduced pressure to get a colorless liquid with a yield of 95%-98% and purity of 95%-97%.
2. Synthesis of N-chloroacetyl-N-isopropyl-p-chloroaniline
N-isopropyl-p-chloroaniline, solvent, chloroacetyl chloride in turn into the reactor, heating and stirring, reaction at a certain temperature for a few hours, add water and stirring, layering, the oil layer washed with water for several times, the water layer was extracted with solvent, the oil layer was combined, the solvent was removed to obtain a light red solid. Yield 98%, purity 96% or more.
3. The synthesis of Sa taipa phosphorus
In the reaction kettle, add N-chloroacetyl-N-isopropyl-p-chloroaniline, acid-binding agent, solvent, and O, O-dimethyl dithiophosphoric acid, at a certain temperature, stirring reaction for a few hours, the end of the reaction add water and stirring, delamination, oil layer washed with water to neutral, desolvation of the finished product of Sabauphos, yield 88% ~ 90%, purity 87% ~ 90%.
