ChemicalBook Product Catalog Organic Chemistry Amides Naphthenic amines derivatives N-Isopropylaniline

N-Isopropylaniline

Product NameN-Isopropylaniline
CAS768-52-5
MFC9H13N
MW135.21
EINECS212-196-7
MOL File768-52-5.mol

Chemical Properties

Melting point	-50 °C
Boiling point	213 °C
Density	0.94
refractive index	1.54
Flash point	88 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	5.77(at 25℃)
form	clear liquid
color	Colorless to Orange to Green
Specific Gravity	0.94
Water Solubility	<0.01 g/100 mL at 21 ºC
BRN	2205871
Henry's Law Constant	1.3×10⁰ mol/(m³Pa) at 25℃, HSDB (2015)
Exposure limits	PC-TWA:10 mg/m3
CAS DataBase Reference	768-52-5(CAS DataBase Reference)
NIST Chemistry Reference	N-Isopropylaniline(768-52-5)
EPA Substance Registry System	N-Isopropylaniline (768-52-5)

Safety Information

Hazard Codes	T
Risk Statements	22-23-36/37/38
Safety Statements	26-36-45-7/9
RIDADR	2810
OEB	B
OEL	TWA: 2 ppm (10 mg/m3) [skin]
WGK Germany	3
RTECS	BY4190000
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	29214990
Hazardous Substances Data	768-52-5(Hazardous Substances Data)

MSDS

Provider	Language
N-Phenylisopropylamine	English
SigmaAldrich	English
ALFA	English

Usage And Synthesis

Chemical Properties

Clear light yellow liquid

Uses

Dyeing of acrylic fibers and as a chemical intermediate

Uses

N-Isopropylaniline is a microbial metabolite of Propachlor (P757300), an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537
Tetrahedron, 52, p. 9777, 1996 DOI: 10.1016/0040-4020(96)00503-0

General Description

N-isopropylaniline is a clear brown liquid. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N-Isopropylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by inhalation and skin absorption.

Health Hazard

N-isopropylaniline absorption causes methemoglobinemia in animals, and the same effect is expected in humans.

Fire Hazard

N-Isopropylaniline is combustible.

Preparation Products And Raw materials

N-Isopropylaniline Supplier

N-Isopropylaniline manufacturers

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