C2 L-erythro Ceramide (d18:1/2:0)

C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is >50% less than that stimulated by C2 ceramide . C2 L-erythro Ceramide also induces cell cycle arrest in the G₀\G₁ phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells. [Matreya, LLC. Catalog No. 1847]

C2 L-Erythro ceramide (d18:1/2:0) is a cell-permeable sphingolipid. C2 L-Erythro ceramide (d18:1/2:0) induces cell cycle arrest in the G0/G1 phase and inhibits cell growth[1][2].

[1] Baek MY, et al. Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells. Arch Pharm Res. 2001 Apr;24(2):144-9. DOI:10.1007/BF02976482
[2] Bielawska A, et al. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993;268(35):26226-26232. PMID:8253743