C6 L-erythro Ceramide (d18:1/6:0)

C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.^1,2 It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC₅₀ = 18 μM).³

1. Schwarz, A., and Futerman, A.H. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth J. Neurosci. 17(9),2929-2938(1997).
2. Paul, P., Kamisaka, Y., Marks, D.L., et al. Purification and characterization of UDP-glucose: Ceramide glucosyltransferase from rat liver Golgi membranes Curr. Opin. Struct. Biol. 271(4),2287-2293(1996).
3. Chang, Y.-T., Choi, J., Ding, S., et al. The synthesis and biological characterization of a ceramide library J. Am. Chem. Soc. 124(9),1856-1857(2002).