Hexamethonium Bromide (0.2-25 mg/kg; i.v.) significantly reduces the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) in the Wistar rats and the spontaneously hypertensive rats (SHRs).
Hexamethonium Bromide (0.2-1.0 mg/kg; i.v.) treatments show no significant differences in the RSNA, MAP or HR between Wistar rats and SHRs.
Hexamethonium Bromide (5.0-25 mg/kg; i.v.) results in a greater reduction in the RSNA and MAP in SHRs compared with Wistar rats.
Animal Model:
Male normotensive Wistar rats (280-320 g), SHRs
Dosage:
0.2 mg/kg, 1.0 mg/kg, 5.0 mg/kg, 25 mg/kg
Administration:
Intravenous injection
Result:
Significantly reduced the RSNA, MAP and HR in the Wistar rats and the SHRs.
