The conventional method for synthesizing N-Boc-2-pyrroleboronic acid starts with pyrrole protected by the hydroxyl precursor Boc. Under the action of a suitable strong base (e.g., LDA), the hydrogen atom at the 2-position of the carbon atom is removed to obtain the corresponding organolithium reagent. Trimethyl borate is then added externally, followed by hydrolysis to obtain the final product. It should be noted that the hydrogen removal process needs to be carried out at ultra-low temperatures, generally -78°C.
