5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.
5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]
[1] LAISING YEN. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.[J]. RNA, 2006, 12 5: 797-806. DOI:
10.1261/rna.2300406[2] THOMAS D SCHMITTGEN. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis.[J]. International journal of oncology, 2005, 27 2: 297-306.
