N-(Azido-PEG2)-N-Boc-PEG4-acid is a N-Boc protected, branched PEG linker with a azido and a terminal carboxylic acid. The azide group enables PEGylation via Click Chemistry. The protected amine can be deprotected under acidic conditions. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU).
N-(Azido-PEG2)-N-Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
