N-(Azido-PEG2)-N-Boc-PEG3-t-butyl ester is a branched PEG molecule with a terminal azide group, Boc protected amine, and a terminal t-butyl ester. The azide group enables Click Chemistry. The Boc protected amine can be deprotected under acidic conditions, and the t-butyl protected carboxyl group can be hydrolyzed nder mild acidic conditions.
N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
